Cell Culture and Virus
نویسنده
چکیده
Canine distemper virus (CDV), a morbillivirus (Paramyxoviridae family) is the causative agent of a serious infection in dogs and other carnivores [2] and has been shown to be antigenically related to other members of the genus [13]. CDV infection in dogs generally is transmitted by inhalation of infectious aerosols. CDV causes acute generalized infection or chronic localized and persistent infection in the central nervous system of dogs [20] and has received great attention throughout the world in recent years. CDV infection may result in subclinical disease, catarrhal form, which consists in gastrointestinal signs and/or respiratory signs, and systemic form characterized with fever, rhinitis, and respiratory problems frequently associated with central nervous system involvement [1,2]. CDV also induces a highly contagious systemic viral infection and often-fatal disease accompanied by a multifocal demyelinating disease in the central nervous system (CNS) in many species of carnivores [12, 24].
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